SCHEMBL2220408

SCHEMBL2220408

C=CC(=O)OS(=O)(=O)c1ccc(N)c2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 1/20 0.41
▸ IDO1 P14902 2/20 0.36
▸ EP300 Q09472 2/20 0.36
▸ KAT8 Q9H7Z6 2/20 0.36
▸ HDAC3 O15379 1/20 0.36
▸ KAT2B Q92831 1/20 0.36
▸ NCOR2 Q9Y618 1/20 0.36
▸ LDHA P00338 1/20 0.36
▸ NSD2 O96028 6/20 0.34
▸ AURKA O14965 1/20 0.34
▸ AURKB Q96GD4 1/20 0.34
▸ SUMO2 P61956 1/20 0.34
▸ SUMO1 P63165 1/20 0.34
▸ SENP7 Q9BQF6 1/20 0.34
▸ SENP3 Q9H4L4 1/20 0.34
▸ SENP2 Q9HC62 1/20 0.34
▸ SENP1 Q9P0U3 1/20 0.34
▸ NR4A1 P22736 1/20 0.33
▸ CDC25B P30305 1/20 0.33
▸ KEAP1 Q14145 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5172344 0.79 CA1 (0.46) NR4A1KEAP1
SCHEMBL2220406 0.76 CA2 (0.52) —
SCHEMBL27898160 0.74 CDC25B (0.42) TTRNSD2CDC25B
SCHEMBL29625173 0.73 THRB (0.36) THRB
SCHEMBL9019320 0.73 TTR (0.50) TTRIDO1EP300KAT8HDAC3
SCHEMBL7470086 0.72 POLB (0.44) THRB
SCHEMBL8839050 0.71 TTR (0.45) TTRIDO1EP300KAT8HDAC3
SCHEMBL10408130 0.71 THRB (0.42) THRB
SCHEMBL1525888 0.70 TTR (0.78) TTRIDO1EP300KAT8HDAC3
SCHEMBL150853 0.70 TTR (0.78) TTRIDO1EP300KAT8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109794849-B Polishing pad with pad wear indicator 罗门哈斯电子材料CMP控股股份有限公司 2021-12-21 — — CN disclosed
US-11192215-B2 Polishing pad with pad wear indicator ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) 2021-12-07 — — US disclosed
US-20190224811-A1 POLISHING PAD WITH PAD WEAR INDICATOR ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. 2019-07-25 — — US disclosed
US-9149440-B2 Nanoparticles for drug-delivery UNIVERSITY OF SOUTH FLORIDA (US) 2015-10-06 — — US disclosed
US-20110175245-A1 ENCAPSULATION THE UNIVERSITY OF MANCHESTER (GB) 2011-07-21 — — US disclosed
EP-2214654-A2 METHOD OF ENCAPSULATION The University Of Manchester (GB) 2010-08-11 — — EP disclosed
WO-2009053711-A2 ENCAPSULATION THE UNIVERSITY OF MANCHESTER (GB) 2009-04-30 — — WO disclosed
US-20070190160-A1 Nanoparticles for drug-delivery UNIVERSITY OF SOUTH FLORIDA 2007-08-16 — — US disclosed
WO-2005020933-A2 NANOPARTICLES FOR DRUG-DELIVERY UNIVERSITY OF SOUTH FLORIDA (US) 2005-03-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070190160-A1 Nanoparticles for drug-delivery EPCAM, TUBB1, ACTB TTR 3001/4885IDO1 4661/4885EP300 3316/4885
US-20110175245-A1 ENCAPSULATION RPS2, MGAM, RPS5 TTR 626/4885IDO1 285/4885EP300 459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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