Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30724547 | 0.90 | SIGMAR1 (0.49) | SIGMAR1ACHE | |
| SCHEMBL27765696 | 0.80 | SIGMAR1 (0.56) | SIGMAR1ACHE | |
| SCHEMBL7723235 | 0.80 | CYP2C19 (0.49) | SIGMAR1 | |
| SCHEMBL22587046 | 0.79 | VEGFA (0.53) | GBA1SIGMAR1HTR1A | |
| Hydrochloric Acid SCHEMBL27476870 | 0.79 | CYP2C19 (0.48) | SIGMAR1 | |
| SCHEMBL27887308 | 0.79 | LTA4H (0.43) | GBA1SIGMAR1ACHE | |
| SCHEMBL27724143 | 0.79 | LTA4H (0.43) | GBA1SIGMAR1ACHE | |
| SCHEMBL2771500 | 0.78 | GBA1 (0.50) | GBA1SIGMAR1MEN1KMT2A | |
| SCHEMBL28041844 | 0.78 | SIGMAR1 (0.41) | SIGMAR1HTR1A | |
| SCHEMBL18834993 | 0.76 | MAPT (0.50) | GBA1SIGMAR1ACHEHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3908283-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2020146613-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |