SCHEMBL22216189

SCHEMBL22216189

CNC/C(=C\F)Cn1cc(C(=O)NC(C)(C)C)cn1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 4/20 0.40
MAOB P27338 1/20 0.40
ACHE P22303 2/20 0.34
LMNA P02545 3/20 0.33
MAPT P10636 2/20 0.33
CYP2C19 P33261 1/20 0.33
GFER P55789 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
HPGD P15428 2/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
SYK P43405 1/20 0.32
KLKB1 P03952 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22216190 0.89 AOC3 (0.42) AOC3MAOBACHELMNAMAPT
SCHEMBL23907200 0.88 AOC3 (0.38) AOC3MAOBACHELMNAMAPT
SCHEMBL23907203 0.88 AOC3 (0.38) AOC3MAOBACHELMNAMAPT
SCHEMBL22216397 0.87 AOC3 (0.51) AOC3MAOBACHELMNAMAPT
SCHEMBL28435846 0.85 AOC3 (0.38) AOC3MAOBACHELMNAMAPT
SCHEMBL29441559 0.85 AOC3 (0.38) AOC3MAOBACHELMNAMAPT
SCHEMBL28894423 0.82 AOC3 (0.44) AOC3MAOBACHELMNAMAPT
SCHEMBL28894427 0.82 AOC3 (0.44) AOC3MAOBACHELMNAMAPT
SCHEMBL22216312 0.81 MAPK11 (0.38) ALDH1A1KLKB1
SCHEMBL23907239 0.79 AOC3 (0.36) AOC3MAOBACHELMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020143763-A1 HALOALLYLAMINE COMPOUNDS AND APPLICATION THEREOF 南京药捷安康生物科技有限公司 2020-07-16 WO disclosed