Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PTPRB | P23467 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTPRA | P18433 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22216498 | 0.85 | SMN1; SMN2 (0.41) | ALDH1A1MMP8RECQLPTPN2PTPN1 | |
| SCHEMBL20350547 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL16865453 | 0.83 | ALDH1A1 (0.57) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL7431853 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL20350605 | 0.75 | MMP8 (0.58) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL6740786 | 0.73 | ALDH1A1 (0.56) | ALDH1A1MMP8RECQLPIN1LMNA | |
| SCHEMBL9199837 | 0.73 | ALDH1A1 (0.47) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL20333385 | 0.72 | MMP8 (0.56) | ALDH1A1MMP8RECQLPIN1PTPN2 | |
| SCHEMBL10821760 | 0.72 | MMP8 (0.63) | ALDH1A1MMP8RECQLPIN1LMNA | |
| SCHEMBL4419400 | 0.72 | ALDH1A1 (0.62) | ALDH1A1MMP8RECQLPIN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034715-B2 | Ectonucleotidase inhibitors and methods of use thereof | CALITHERA BIOSCIENCES, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200223882-A1 | Ectonucleotidase Inhibitors and Methods of Use Thereof | ANTENGENE THERAPEUTICS LIMITED (CN) | 2020-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200223882-A1 | Ectonucleotidase Inhibitors and Methods of Use Thereof | NT5E, ENTPD5, NT5C2 | ALDH1A1 527/4885MMP8 214/4885RECQL 644/4885 |
| US-11034715-B2 | Ectonucleotidase inhibitors and methods of use thereof | NT5E, ENTPD5, NT5C2 | ALDH1A1 527/4885MMP8 214/4885RECQL 644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.