Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8328761 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL275423 | 0.91 | — | — | |
| Succinic Acid SCHEMBL9181910 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL10785057 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL1462992 | 0.91 | — | — | |
| Succinic Acid SCHEMBL1665207 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL21958270 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL22471655 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL21958272 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL5685913 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117338947-A | Hydroxyalkyl starch-photosensitizer coupled amphiphilic macromolecular compound, nano drug-loading system, preparation method and application thereof | 华中科技大学 | 2024-01-05 | — | — | CN | disclosed |
| US-20130017265-A1 | PARTICLES FOR MULTIPLE AGENT DELIVERY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-01-17 | — | — | US | disclosed |
| EP-2512522-A2 | PARTICLES FOR MULTIPLE AGENT DELIVERY | Brigham and Women's Hospital, Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011084620-A2 | PARTICLES FOR MULTIPLE AGENT DELIVERY | BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
| US-7138520-B2 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-11-21 | — | — | US | disclosed |
| US-20040235712-A1 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235712-A1 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same | EPCAM, PAICS, CD47 | FFAR3 4322/4885HDAC3 599/4885HDAC1 332/4885 |
| US-20130017265-A1 | PARTICLES FOR MULTIPLE AGENT DELIVERY | PGF, HDGF, MMP7 | FFAR3 3940/4885HDAC3 1844/4885HDAC1 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.