Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4648245 | 0.72 | KMT2A (0.54) | P2RX4MEN1HPGDKMT2ATSHR | |
| SCHEMBL2223563 | 0.70 | TSHR (0.50) | MEN1KMT2ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL1161528 | 0.66 | FAAH (0.40) | P2RX4MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL1161808 | 0.64 | SCN9A (0.42) | P2RX4MEN1HPGDKMT2ATSHR | |
| SCHEMBL4659663 | 0.64 | MEN1 (0.33) | P2RX4MEN1HPGDKMT2ATSHR | |
| SCHEMBL3943731 | 0.63 | HDAC8 (0.42) | P2RX4ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL9987413 | 0.63 | P2RX4 (0.39) | P2RX4MEN1HPGDKMT2ATSHR | |
| SCHEMBL19623129 | 0.61 | ALDH1A1 (0.49) | MEN1KMT2ATSHRALDH1A1RAB9A | |
| SCHEMBL162880 | 0.61 | KMT2A (0.58) | P2RX4MEN1HPGDKMT2ATSHR | |
| SCHEMBL159377 | 0.61 | P2RX4 (0.40) | P2RX4MEN1HPGDKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729149-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013006596-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2013-01-10 | — | — | WO | disclosed |
| EP-2523665-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | Glaxo Group Limited (GB) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088201-A1 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | WO | disclosed |