Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659624 | 0.83 | TSHR (0.32) | MEN1KMT2AHPGDP2RX4TSHR | |
| SCHEMBL2223563 | 0.68 | TSHR (0.50) | MEN1KMT2ATSHRALDH1A1KDM4E | |
| SCHEMBL2222809 | 0.64 | P2RX4 (0.37) | MEN1KMT2AHPGDP2RX4TSHR | |
| SCHEMBL3943731 | 0.64 | HDAC8 (0.42) | P2RX4ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL4658528 | 0.64 | AAK1 (0.36) | MEN1KMT2AHPGDP2RX4 | |
| SCHEMBL4767343 | 0.64 | ELANE (0.46) | MEN1KMT2AMAPT | |
| SCHEMBL10687 | 0.63 | KMO (0.46) | MEN1KMT2AP2RX4ALDH1A1MAPT | |
| SCHEMBL14720210 | 0.62 | NTSR1 (0.46) | MEN1KMT2AHPGDP2RX4TSHR | |
| SCHEMBL1161341 | 0.62 | KCNMA1 (0.50) | MEN1KMT2AHPGDP2RX4TSHR | |
| SCHEMBL17311564 | 0.62 | ELANE (0.50) | P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720855-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1720855-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085227-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |