SCHEMBL22229877

SCHEMBL22229877

Oc1ccc(-c2nc(-c3ccccn3)c(-c3ccccn3)[nH]2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 6/20 0.57
MAPK14 Q16539 7/20 0.55
MAPK13 O15264 5/20 0.55
MAPK12 P53778 5/20 0.55
MAPK11 Q15759 5/20 0.55
RAF1 P04049 3/20 0.55
BRAF P15056 3/20 0.55
MAPT P10636 5/20 0.51
TP53 P04637 3/20 0.51
GCGR P47871 2/20 0.51
ACVR1B P36896 3/20 0.50
AURKA O14965 1/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
CSNK1D P48730 4/20 0.49
CSNK1A1 P48729 3/20 0.49
CSNK1E P49674 3/20 0.49
KDM4E B2RXH2 2/20 0.49
RIPK2 O43353 2/20 0.49
PRKD3 O94806 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19868997 0.88 TGFBR1 (0.74) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL18292652 0.88 MAPK14 (0.61) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL5139175 0.81 TGFBR1 (0.79) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL38664148 0.78 NPC1 (0.46) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL4869167 0.74 NPY5R (0.56) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL4079452 0.74 TGFBR1 (0.71) TGFBR1MAPK14MAPK13MAPK12MAPK11
SCHEMBL252964 0.73 MAPK13 (0.85) MAPK14MAPK13MAPK12MAPK11RAF1
SCHEMBL9619859 0.73 MAPK13 (0.85) MAPK14MAPK13MAPK12MAPK11RAF1
SCHEMBL15401173 0.73 MAPK13 (0.85) MAPK14MAPK13MAPK12MAPK11RAF1
SCHEMBL18292488 0.73 MAPK13 (0.85) MAPK14MAPK13MAPK12MAPK11RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111454718-B Ultrasensitive chemiluminescent substrates for peroxidases 喜雅纳肯有限公司 2025-01-03 CN disclosed
US-20230417755-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE CYANAGEN S R L (IT) 2023-12-28 US disclosed
EP-3686285-B1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE CYANAGEN S R L (IT) 2023-10-11 EP disclosed
US-11761964-B2 Ultra-sensitive chemiluminescent substrates for peroxidase CYANAGEN S.R.L. (IT) 2023-09-19 US disclosed
CN-116466091-A Kit for detecting IgA immune complex based on chemiluminescence method 深圳市陆为生物技术有限公司 2023-07-21 CN disclosed
EP-3686285-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE Cyanagen S.r.l. (IT) 2020-07-29 EP disclosed
US-20200232991-A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR PEROXIDASE CYANAGEN S.R.L. (IT) 2020-07-23 US disclosed