Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.52 |
| ▸ | RAF1 | P04049 | 6/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18292652 | 0.85 | MAPK14 (0.61) | NPY5RMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9736817 | 0.79 | MAPK13 (0.71) | NPY5RMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6223466 | 0.77 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL28403314 | 0.76 | MAPK13 (0.61) | NPY5RMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4551941 | 0.75 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL22229877 | 0.74 | TGFBR1 (0.57) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| [2,3'']Bipyridinyl SCHEMBL29486847 | 0.73 | CYP2A6 (1.00) | CYP2A6PIM1PIM2CYP19A1KDM4E | |
| [2,3'']Bipyridinyl SCHEMBL29360744 | 0.73 | CYP2A6 (1.00) | CYP2A6PIM1PIM2CYP19A1KDM4E | |
| [2,3'']Bipyridinyl SCHEMBL998601 | 0.73 | CYP2A6 (1.00) | CYP2A6PIM1PIM2CYP19A1KDM4E | |
| [2,3'']Bipyridinyl SCHEMBL29389597 | 0.73 | CYP2A6 (1.00) | CYP2A6PIM1PIM2CYP19A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | NPY5R 1073/4885CYP2A6 157/4885MAPK13 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.