Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24373507 | 0.83 | MPO (0.45) | MPOPABPC1ACHEBACE1HRH4 | |
| SCHEMBL2725328 | 0.76 | MDM4 (0.45) | MPOACHEBACE1HTTPDPK1 | |
| SCHEMBL14001902 | 0.75 | HSD17B10 (0.52) | ACHEBACE1HTTNQO2RAB9A | |
| SCHEMBL11728816 | 0.72 | PABPC1 (0.61) | PABPC1ACHEBACE1HTTPDPK1 | |
| SCHEMBL22234179 | 0.71 | NLRP3 (0.52) | JAK2NPC1RAB9A | |
| SCHEMBL29522929 | 0.71 | NLRP3 (0.52) | JAK2NPC1RAB9A | |
| SCHEMBL22234174 | 0.70 | HTT (0.50) | MPOPABPC1ACHEBACE1HRH4 | |
| SCHEMBL7427955 | 0.70 | MPO (0.46) | MPOACHEBACE1HRH4F2 | |
| SCHEMBL6791268 | 0.70 | F2 (0.51) | MPOACHEHRH4F2HTT | |
| SCHEMBL5498929 | 0.70 | HRH4 (0.50) | MPOPABPC1ACHEBACE1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12338228-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-20220089566-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. | 2022-03-24 | — | — | US | disclosed |
| EP-3911642-A1 | NLRP3 MODULATORS | Innate Tumor Immunity, Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| CN-113286787-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2021-08-20 | — | — | CN | disclosed |
| WO-2020150116-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150116-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2020-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089566-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | MPO 150/4885PABPC1 1147/4885ACHE 4883/4885 |
| US-12338228-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | MPO 150/4885PABPC1 1147/4885ACHE 4883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.