Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235603 | 0.85 | WNT1 (0.46) | ALDH1A1DYRK1AWNT1TSHRGAA | |
| SCHEMBL22236099 | 0.83 | NAMPT (0.53) | SGMS2NAMPTGAAKMT2APKM | |
| SCHEMBL22235674 | 0.82 | KDR (0.51) | SGMS2NAMPTGAAHDAC6SMN1; SMN2 | |
| SCHEMBL22235858 | 0.82 | NAMPT (0.46) | ALDH1A1NAMPTGAAKMT2AHDAC6 | |
| SCHEMBL22235634 | 0.76 | RXFP1 (0.46) | TP53 | |
| SCHEMBL25415696 | 0.76 | RAB9A (0.51) | ALDH1A1TDP1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL30520324 | 0.76 | RAB9A (0.51) | ALDH1A1TDP1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL22258490 | 0.74 | SMN1; SMN2 (0.40) | DYRK1AWNT1GAASMN1; SMN2 | |
| SCHEMBL22236083 | 0.73 | SMN1; SMN2 (0.49) | ALDH1A1NAMPTTDP1SMN1; SMN2KDM4E | |
| SCHEMBL22235679 | 0.73 | LMNA (0.68) | ALDH1A1DYRK1ATSHRNAMPTCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |