Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | CLK3 | P49761 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22235826 | 0.99 | WNT1 (0.46) | WNT1KCNQ3KCNQ2DYRK1ACLK2 | |
| SCHEMBL22258557 | 0.89 | STAT6 (0.41) | WNT1KCNQ3KCNQ2DYRK1ACLK2 | |
| SCHEMBL22258556 | 0.87 | TRPV1 (0.41) | WNT1KCNQ3KCNQ2DYRK1ACLK2 | |
| SCHEMBL22235752 | 0.84 | CDK5 (0.43) | WNT1DYRK1ACLK2CLK3TRPV1 | |
| SCHEMBL22235835 | 0.79 | SMN1; SMN2 (0.56) | WNT1KCNQ3KCNQ2DYRK1ACLK2 | |
| SCHEMBL22236104 | 0.79 | RXFP1 (0.47) | RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL22236025 | 0.79 | KCNQ3 (0.50) | WNT1KCNQ3KCNQ2DYRK1ACLK2 | |
| SCHEMBL22279080 | 0.77 | ALDH1A1 (0.53) | STAT6RAB9ACYP1A2KDM4EALDH1A1 | |
| SCHEMBL22777877 | 0.76 | RECQL (0.51) | KCNQ3KCNQ2TRPV1DGAT1L3MBTL1 | |
| SCHEMBL22236099 | 0.76 | NAMPT (0.53) | RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |