Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 7/20 | 0.43 |
| ▸ | CLK3 | P49761 | 7/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22258547 | 0.89 | LTA4H (0.39) | CDK5CDK5R1CLK2CLK3DYRK1A | |
| SCHEMBL22235826 | 0.85 | WNT1 (0.46) | CLK2CLK3DYRK1ATRPV1WNT1 | |
| SCHEMBL22236264 | 0.84 | WNT1 (0.46) | CLK2CLK3DYRK1ATRPV1WNT1 | |
| SCHEMBL22235999 | 0.83 | CDK5 (0.62) | CDK5CDK5R1HRH3ALDH1A1 | |
| SCHEMBL22236104 | 0.78 | RXFP1 (0.47) | ALDH1A1 | |
| SCHEMBL22235847 | 0.77 | MEN1 (0.42) | CLK2CLK3DYRK1AHTR2C | |
| SCHEMBL22236099 | 0.75 | NAMPT (0.53) | GAAPOLBLTA4H | |
| SCHEMBL22235940 | 0.74 | EGFR (0.65) | GAA | |
| SCHEMBL17239852 | 0.73 | HRH3 (0.46) | HRH3GAATRPV1HTR2CMCHR1 | |
| SCHEMBL22258286 | 0.72 | MAPT (0.49) | GAAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |
| WO-2020150545-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE WNT/B-CATENIN SIGNALING PATHWAY | SAMUMED, LLC (US) | 2020-07-23 | — | — | WO | disclosed |