Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.32 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.32 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.32 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.31 |
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | GABRE | P78334 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239573 | 0.73 | QPCT (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20385718 | 0.67 | NOS3 (0.43) | ASIC3NOS3NOS1NOS2 | |
| SCHEMBL18568712 | 0.66 | NOS3 (0.48) | ASIC3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL17770071 | 0.61 | HTR1A (0.33) | CDC7DBF4 | |
| SCHEMBL17770068 | 0.61 | HTR1A (0.33) | CDC7DBF4 | |
| SCHEMBL28584959 | 0.59 | TSHR (0.30) | TSHR | |
| SCHEMBL3498257 | 0.59 | ASIC3 (0.54) | ASIC3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL26081246 | 0.59 | TSHR (0.41) | USP2TSHR | |
| SCHEMBL26081240 | 0.59 | NOS3 (0.47) | HRH3GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2879167 | 0.58 | P2RX7 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |