Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.40 |
| ▸ | CHI3L1 | P36222 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.39 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.39 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239569 | 0.76 | HRH4 (0.39) | KDM4EHPGDTSHRHSD17B10KCNH2 | |
| SCHEMBL22239935 | 0.76 | HRH4 (0.39) | KDM4EHPGDTSHRHSD17B10KCNH2 | |
| SCHEMBL22239854 | 0.74 | CHI3L1 (0.33) | USP30CHI3L1KCNH2CHIT1CHI3L2 | |
| SCHEMBL18129069 | 0.67 | MAP4K4 (0.56) | KDM4ELMNAMAPTHPGDTSHR | |
| SCHEMBL23875675 | 0.65 | GRM1 (0.51) | USP30KDM4EMAPTTSHRAVPR1A | |
| SCHEMBL8091809 | 0.65 | GRM1 (0.51) | USP30KDM4EMAPTTSHRAVPR1A | |
| SCHEMBL30146648 | 0.65 | MAP4K4 (0.52) | USP30KDM4EHPGDHSD17B10AVPR1A | |
| SCHEMBL20632760 | 0.65 | OPRK1 (0.33) | KDM4ETSHRHSD17B10PDE10AALDH1A1 | |
| SCHEMBL359401 | 0.65 | PLD1 (0.58) | KDM4EMAPTTSHRAVPR1AGPR119 | |
| SCHEMBL29774590 | 0.65 | PLD1 (0.58) | KDM4EMAPTTSHRAVPR1AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |