Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHI3L1 | P36222 | 13/20 | 0.33 |
| ▸ | CHIA | Q9BZP6 | 6/20 | 0.33 |
| ▸ | CHIT1 | Q13231 | 5/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.33 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22239724 | 0.84 | TRPV1 (0.31) | CNR1CNR2 | |
| SCHEMBL19714486 | 0.76 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL19713805 | 0.76 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL19736435 | 0.76 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL19714367 | 0.76 | CNR2 (0.38) | CNR1CNR2 | |
| SCHEMBL22240222 | 0.74 | USP30 (0.41) | CHI3L1CHIACHIT1KCNH2CHI3L2 | |
| SCHEMBL22240289 | 0.74 | LPL (0.35) | CNR1CNR2 | |
| SCHEMBL22240292 | 0.73 | MEN1 (0.32) | CNR1CNR2 | |
| SCHEMBL22240215 | 0.72 | NOS2 (0.32) | — | |
| SCHEMBL22239961 | 0.72 | AXL (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |