Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 3/20 | 0.35 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222588 | 0.92 | S1PR1 (0.52) | S1PR1CYP1A2CYP2C19CYP3A4HPGD | |
| SCHEMBL2222899 | 0.89 | S1PR1 (0.51) | S1PR1CYP1A2CYP2C19CYP3A4HPGD | |
| SCHEMBL2223699 | 0.87 | S1PR1 (0.45) | S1PR1CYP1A2CYP2C19CYP3A4TP53 | |
| SCHEMBL2222853 | 0.87 | S1PR1 (0.58) | S1PR1CYP1A2CYP2C19CYP3A4HPGD | |
| SCHEMBL2224919 | 0.86 | S1PR1 (0.49) | S1PR1CYP1A2CYP2C19HPGDMAPT | |
| SCHEMBL14797341 | 0.85 | S1PR1 (0.76) | S1PR1HPGDMAPTTP53NPSR1 | |
| SCHEMBL2223355 | 0.84 | S1PR1 (0.73) | S1PR1CYP1A2CYP2C19CYP3A4HPGD | |
| SCHEMBL2222985 | 0.83 | S1PR1 (0.52) | S1PR1CYP1A2CYP2C19CYP3A4MAPT | |
| SCHEMBL2224653 | 0.83 | S1PR1 (0.56) | S1PR1CYP1A2CYP2C19CYP3A4HPGD | |
| SCHEMBL2223206 | 0.82 | S1PR1 (0.47) | S1PR1CYP1A2CYP2C19CYP3A4MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |