Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 3/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222541 | 0.90 | S1PR1 (0.51) | S1PR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2224919 | 0.86 | S1PR1 (0.49) | S1PR1CYP1A2CYP2C19CEPT1SMN1; SMN2 | |
| SCHEMBL14797000 | 0.85 | S1PR1 (0.74) | S1PR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2224913 | 0.85 | S1PR1 (0.47) | S1PR1CYP1A2CYP3A4CYP2C19CEPT1 | |
| SCHEMBL2223206 | 0.85 | S1PR1 (0.47) | S1PR1CYP1A2CYP3A4CYP2C19CEPT1 | |
| SCHEMBL2225559 | 0.84 | S1PR1 (0.49) | S1PR1CYP1A2CYP3A4CEPT1MAPT | |
| SCHEMBL2222186 | 0.84 | S1PR1 (0.48) | S1PR1CYP1A2CYP3A4CEPT1MAPT | |
| SCHEMBL2224286 | 0.83 | S1PR1 (0.54) | S1PR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2223355 | 0.82 | S1PR1 (0.73) | S1PR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2222588 | 0.82 | S1PR1 (0.52) | S1PR1CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |