Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222588 | 0.93 | S1PR1 (0.52) | S1PR1CYP3A4CYP1A2CYP2C19HPGD | |
| SCHEMBL2222292 | 0.90 | S1PR1 (0.44) | S1PR1 | |
| SCHEMBL2222071 | 0.90 | S1PR1 (0.44) | S1PR1HPGDTP53MAPTHSD17B10 | |
| SCHEMBL2224286 | 0.89 | S1PR1 (0.54) | S1PR1CYP3A4CYP1A2CYP2C19HPGD | |
| SCHEMBL2222186 | 0.88 | S1PR1 (0.48) | S1PR1CYP3A4CYP1A2HPGDTP53 | |
| SCHEMBL2224913 | 0.86 | S1PR1 (0.47) | S1PR1CYP3A4CYP1A2CYP2C19HPGD | |
| SCHEMBL2223727 | 0.86 | S1PR1 (0.47) | S1PR1HPGDTP53MAPTHSD17B10 | |
| SCHEMBL2223599 | 0.86 | S1PR1 (0.47) | S1PR1TP53MAPTAPPCETP | |
| SCHEMBL14797056 | 0.85 | S1PR1 (0.73) | S1PR1HPGDTP53MAPTNPSR1 | |
| SCHEMBL2222853 | 0.84 | S1PR1 (0.58) | S1PR1CYP3A4CYP1A2CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523962-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086079-A1 | CARBOXYLIC ACID DERIVATIVES HAVING A 2,5-SUBSTITUTED OXAZOLOPYRIMIDINE RING | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | WO | disclosed |