Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 2/20 | 0.67 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.58 |
| ▸ | PRKDC | P78527 | 11/20 | 0.58 |
| ▸ | SRC | P12931 | 10/20 | 0.58 |
| ▸ | ABL1 | P00519 | 9/20 | 0.58 |
| ▸ | EGFR | P00533 | 9/20 | 0.58 |
| ▸ | HCK | P08631 | 9/20 | 0.58 |
| ▸ | MTOR | P42345 | 9/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.58 |
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22692820 | 0.86 | NUDT14 (0.75) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22230768 | 0.83 | BTK (0.68) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL30381806 | 0.83 | BTK (0.68) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL130752 | 0.82 | NUDT14 (0.74) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22230811 | 0.81 | BTK (0.60) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22230587 | 0.81 | BTK (0.60) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22230589 | 0.81 | BTK (0.60) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL130529 | 0.81 | NUDT14 (1.00) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22230465 | 0.80 | EGFR (0.61) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22243274 | 0.80 | BTK (0.54) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072270-A1 | PROTAC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 百极弘烨(南通)医药科技有限公司 | 2023-05-04 | — | — | WO | disclosed |
| WO-2020147798-A1 | CYCLIC MOLECULES AS BRUTON'S TYROSINE KINASE INHIBITOR | 明慧医药（上海）有限公司 | 2020-07-23 | — | — | WO | disclosed |