Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 2/20 | 1.00 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.74 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.74 |
| ▸ | PRKDC | P78527 | 7/20 | 0.74 |
| ▸ | SRC | P12931 | 8/20 | 0.67 |
| ▸ | KDR | P35968 | 7/20 | 0.67 |
| ▸ | EGFR | P00533 | 7/20 | 0.67 |
| ▸ | ABL1 | P00519 | 5/20 | 0.67 |
| ▸ | HCK | P08631 | 5/20 | 0.67 |
| ▸ | MTOR | P42345 | 5/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.67 |
| ▸ | BTK | Q06187 | 10/20 | 0.66 |
| ▸ | LCK | P06239 | 6/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | TEK | Q02763 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
| ▸ | ITK | Q08881 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409367 | 0.88 | PIK3CD (0.82) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL15613570 | 0.87 | PIK3CD (0.81) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22692820 | 0.86 | NUDT14 (0.75) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL18176199 | 0.86 | NUDT14 (0.75) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL130425 | 0.85 | PIK3CD (1.00) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL130752 | 0.85 | NUDT14 (0.74) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22692814 | 0.84 | NUDT14 (0.72) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL22909341 | 0.84 | NUDT14 (0.72) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL24192635 | 0.84 | NUDT14 (0.72) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB | |
| SCHEMBL25069027 | 0.84 | SRC (0.76) | NUDT14NUDT5PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024086361-A1 | MOLECULAR GLUE DEGRADER COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2024-04-25 | — | — | WO | disclosed |
| US-11858907-B2 | Kinase modulators | RHIZEN PHARMACEUTICALS AG (CH) | 2024-01-02 | — | — | US | disclosed |
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |
| WO-2023066350-A1 | CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS | 标新生物医药科技(上海)有限公司 | 2023-04-27 | — | — | WO | disclosed |
| US-20230126711-A1 | ENTERIC NITRERGIC NEURONS AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-04-27 | — | — | US | disclosed |
| US-20230126711-A1 | ENTERIC NITRERGIC NEURONS AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-04-27 | — | — | US | disclosed |
| US-20230055961-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | DUNAD THERAPEUTICS LTD. (GB) | 2023-02-23 | — | — | US | disclosed |
| WO-2023284703-A1 | PROTEIN DEGRADATION COMPOUND DESIGNED ON THE BASIS OF BRUTON'S TYROSINE KINASE LIGAND AND APPLICATION THEREOF | 标新生物医药科技(上海)有限公司 | 2023-01-19 | — | — | WO | disclosed |
| US-11542266-B1 | Substituted piperidines as BTK inhibitors | HAISCO PHARMACEUTICALS PTE. LTD. (SG) | 2023-01-03 | — | — | US | disclosed |
| WO-2022253250-A1 | BRUTON'S TYROSINE KINASE DEGRADER CONTAINING FUSED-RING OR SPIRO-RING | 正大天晴药业集团股份有限公司 | 2022-12-08 | — | — | WO | disclosed |
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2015-11-12 | — | — | US | disclosed |
| US-20150174131-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS AG (CH) | 2015-06-25 | — | — | US | disclosed |
| US-9018375-B2 | Substituted chromenes as kinase modulators | RHIZEN PHARMACEUTICALS SA (CH) | 2015-04-28 | — | — | US | disclosed |
| US-8952015-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2014-03-20 | — | — | US | disclosed |
| US-8642607-B2 | 4H-chromen-4-one compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2014-02-04 | — | — | US | disclosed |
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-15 | — | — | US | disclosed |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2012-03-08 | — | — | US | disclosed |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | RHIZEN PHARMACEUTICALS SA (CH) | 2011-05-19 | — | — | US | disclosed |
| US-20110039868-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150174131-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | NUDT14 1304/4885NUDT5 2607/4885PIK3CD 70/4885 |
| US-20150320752-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | NUDT14 1403/4885NUDT5 2424/4885PIK3CD 47/4885 |
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | NUDT14 1403/4885NUDT5 2424/4885PIK3CD 47/4885 |
| US-20140080827-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | NUDT14 1304/4885NUDT5 2607/4885PIK3CD 70/4885 |
| US-20230055961-A1 | PENTAFLUOROBENZENESULFONAMIDE DERIVATIVES AND USES THEREOF | FURIN, PFAS, CFTR | NUDT14 1025/4885NUDT5 1619/4885PIK3CD 2856/4885 |
| US-20110118257-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | NUDT14 1304/4885NUDT5 2607/4885PIK3CD 70/4885 |
| US-20110039868-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, LCK, LYN | NUDT14 3005/4885NUDT5 2890/4885PIK3CD 98/4885 |
| US-11542266-B1 | Substituted piperidines as BTK inhibitors | BTK, BLK, SYK | NUDT14 3824/4885NUDT5 2932/4885PIK3CD 49/4885 |
| US-20230126711-A1 | ENTERIC NITRERGIC NEURONS AND METHODS OF USING THE SAME | PROX1, MYH2, NOS2 | NUDT14 673/4885NUDT5 720/4885PIK3CD 3440/4885 |
| US-11858907-B2 | Kinase modulators | RPS6KA1, RPS6KA2, PRKAR2A | NUDT14 2673/4885NUDT5 3615/4885PIK3CD 103/4885 |
| US-20120059001-A1 | NOVEL KINASE MODULATORS | PRKCA, PRKCH, PRKCB | NUDT14 1304/4885NUDT5 2607/4885PIK3CD 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.