Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226730 | 0.84 | LMNA (0.55) | LMNAHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL2224488 | 0.83 | TGM2 (0.60) | LMNAHSD17B10F13A1TGM2TGM1 | |
| SCHEMBL2225293 | 0.73 | ALDH1A1 (0.57) | LMNAMAPTKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL12693450 | 0.71 | MAPT (0.56) | LMNAHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL693208 | 0.71 | MAPT (0.55) | LMNAHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL2228142 | 0.70 | IRAK4 (0.43) | LMNAKDM4E | |
| SCHEMBL2224010 | 0.70 | LMNA (0.49) | LMNAHSD17B10MAPTKMT2AMAPK1 | |
| SCHEMBL3913162 | 0.70 | MAPT (0.50) | LMNAMAPTMAPK1ALDH1A1HTT | |
| SCHEMBL308445 | 0.69 | F13A1 (0.46) | TSHRF13A1TGM2TGM1 | |
| SCHEMBL1430098 | 0.69 | F13A1 (0.46) | TSHRF13A1TGM2TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533782-A1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | Convergence Pharmaceuticals Limited (GB) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011086377-A1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | Convergence Pharmaceuticals Limited (GB) | 2011-07-21 | — | — | WO | disclosed |