Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224490 | 0.84 | LMNA (0.52) | LMNAHSD17B10KDM4EMAPTMEN1 | |
| SCHEMBL2226727 | 0.81 | TGM2 (0.64) | LMNAHSD17B10KDM4EMAPT | |
| SCHEMBL14490213 | 0.78 | TGM2 (0.59) | LMNAHSD17B10MAPTMEN1KMT2A | |
| SCHEMBL5436955 | 0.75 | SMN1; SMN2 (0.52) | LMNAMAPTPOLBSMN1; SMN2TSHR | |
| SCHEMBL1156054 | 0.74 | L3MBTL1 (0.65) | LMNAMEN1MAPK1KMT2AALDH1A1 | |
| SCHEMBL15010193 | 0.73 | L3MBTL1 (0.62) | LMNAMEN1KMT2AALDH1A1POLB | |
| SCHEMBL3654102 | 0.72 | P2RX7 (0.51) | HSD17B10MEN1KMT2AALDH1A1 | |
| SCHEMBL14501626 | 0.72 | L3MBTL1 (0.65) | LMNAKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL12626344 | 0.71 | EPHX2 (0.48) | LMNAKDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL3133674 | 0.71 | L3MBTL1 (0.52) | MEN1MAPK1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533782-A1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | Convergence Pharmaceuticals Limited (GB) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011086377-A1 | PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS | Convergence Pharmaceuticals Limited (GB) | 2011-07-21 | — | — | WO | disclosed |