SCHEMBL2224522

SCHEMBL2224522

Clc1c[c]c(Cl)c(-c2ccccc2Br)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPK14 Q16539 2/20 0.36
GCGR P47871 1/20 0.36
HSD11B1 P28845 1/20 0.34
MAOB P27338 2/20 0.33
MAOA P21397 1/20 0.33
S100A4 P26447 1/20 0.33
TSHR P16473 3/20 0.33
HPGD P15428 3/20 0.33
TDP1 Q9NUW8 3/20 0.31
KMT2A Q03164 1/20 0.31
PDK2 Q15119 1/20 0.31
PBRM1 Q86U86 1/20 0.31
IDO1 P14902 1/20 0.31
LMNA P02545 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4284885 0.77 HPGD (0.39) MAPK1ALDH1A1MAOAS100A4TSHR
SCHEMBL9004936 0.76 MAPK1 (0.41) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL25893596 0.75 S100A4 (0.52) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL31465795 0.74 S100A4 (0.55) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL9784010 0.73 NOTUM (0.37) MAPK1MAOATSHRIDO1
SCHEMBL2224527 0.72 ALDH1A1 (0.38) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL23487149 0.71 MAPK1 (0.56) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL30968565 0.71 S100A4 (0.47) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL31674872 0.71 S100A4 (0.47) MAPK1ALDH1A1MAPK14GCGRHSD11B1
SCHEMBL17068901 0.71 S100A4 (0.47) MAPK1ALDH1A1MAPK14GCGRHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2651219-A2 FUNGICIDAL AZOCYCLIC AMIDES E.I. Du Pont De Nemours And Company (US) 2013-10-23 EP disclosed
EP-2521450-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E.I. Du Pont De Nemours And Company (US) 2012-11-14 EP disclosed
WO-2012082580-A2 FUNGICIDAL AZOCYCLIC AMIDES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2012-06-21 WO disclosed
WO-2011085170-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-07-14 WO disclosed