Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26200516 | 0.84 | ALDH1A1 (0.44) | ALDH1A1POLBKDM4ENPC1HPGD | |
| SCHEMBL22246046 | 0.82 | KMT2A (0.44) | ALDH1A1POLBKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL22246047 | 0.75 | KMT2A (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL22246091 | 0.73 | PTGS1 (0.63) | ALDH1A1KDM4ENPC1HPGDRAB9A | |
| SCHEMBL22246092 | 0.73 | KMT2A (0.47) | ALDH1A1KMT2A | |
| SCHEMBL521943 | 0.73 | ALDH1A1 (0.62) | ALDH1A1POLBKDM4ENPC1HPGD | |
| SCHEMBL22246048 | 0.72 | PTGS2 (0.46) | KDM4EHPGDSMN1; SMN2KMT2AADORA2A | |
| SCHEMBL22246009 | 0.72 | KMT2A (0.36) | ALDH1A1POLBKDM4ENPC1HPGD | |
| SCHEMBL22246051 | 0.72 | ALDH1A1 (0.47) | ALDH1A1POLBKDM4ENPC1HPGD | |
| SCHEMBL22246017 | 0.72 | PTGS1 (0.37) | ALDH1A1POLBKDM4ENPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-09-05 | — | — | US | disclosed |
| US-20220087992-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-03-24 | — | — | US | disclosed |
| US-11191752-B2 | Compounds and methods of treating retinal degeneration | CASE WESTERN RESERVE UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| US-20200230119-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | CASE WESTERN RESERVE UNIVERSITY | 2020-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220087992-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | ALDH1A2, PDE6D, PDE6C | ALDH1A1 212/4885POLB 818/4885KDM4E 4656/4885 |
| US-20200230119-A1 | COMPOUNDS AND METHODS OF TREATING RETINAL DEGENERATION | PDE6A, PDE6H, PDE6D | ALDH1A1 1072/4885POLB 1698/4885KDM4E 4822/4885 |
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | ALDH1A2, PDE6D, PDE6C | ALDH1A1 212/4885POLB 818/4885KDM4E 4656/4885 |
| US-11191752-B2 | Compounds and methods of treating retinal degeneration | PDE6A, PDE6H, PDE6D | ALDH1A1 1072/4885POLB 1698/4885KDM4E 4822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.