Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22246016 | 0.84 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL26200495 | 0.73 | LTA4H (0.33) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL26200515 | 0.73 | LTA4H (0.33) | MAPT | |
| SCHEMBL521943 | 0.72 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL29696576 | 0.66 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL22246046 | 0.65 | KMT2A (0.44) | ALDH1A1HPGDKDM4ESMN1; SMN2POLB | |
| SCHEMBL3087312 | 0.65 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL18671634 | 0.63 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL28741694 | 0.63 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ENPC1RAB9A | |
| SCHEMBL3087314 | 0.63 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | CASE WESTERN RESERVE UNIVERSITY (US) | 2023-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11744826-B2 | Compounds and methods of treating retinal degeneration | ALDH1A2, PDE6D, PDE6C | ALDH1A1 212/4885HPGD 238/4885KDM4E 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.