Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20657797 | 0.78 | ERN1 (0.39) | PRKDCERN1LMNACYP1A2CYP3A4 | |
| SCHEMBL14966255 | 0.78 | ERN1 (0.31) | PRKDCERN1 | |
| SCHEMBL2237276 | 0.72 | PRKDC (0.58) | PRKDCERN1LMNATRIM24TRIM33 | |
| SCHEMBL20657830 | 0.72 | KMT2A (0.40) | LMNA | |
| SCHEMBL22246384 | 0.72 | KMT2A (0.34) | CYP3A4 | |
| SCHEMBL29950791 | 0.68 | PRKDC (0.41) | PRKDCERN1LMNATRIM24TRIM33 | |
| SCHEMBL790844 | 0.68 | BACE1 (0.50) | ERN1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL18382141 | 0.68 | PRKDC (0.54) | PRKDCERN1LMNATRIM24TRIM33 | |
| SCHEMBL31649818 | 0.67 | ERN1 (0.48) | PRKDCERN1LMNATRIM24TRIM33 | |
| SCHEMBL29952291 | 0.67 | PRKDC (0.48) | PRKDCERN1LMNATRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150676-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-07-23 | — | — | WO | disclosed |