Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17299128 | 0.77 | KMT2A (0.36) | KMT2AHTTPOLBL3MBTL1MAPT | |
| SCHEMBL24550677 | 0.73 | HTT (0.38) | KMT2AHTTPOLBL3MBTL1MAPT | |
| SCHEMBL1565399 | 0.73 | LMNA (0.44) | KMT2AHTTPOLBL3MBTL1MAPT | |
| SCHEMBL1564745 | 0.73 | TDP1 (0.34) | KMT2AHTTPOLBL3MBTL1MAPT | |
| SCHEMBL22246385 | 0.72 | PRKDC (0.37) | CYP3A4 | |
| SCHEMBL22246390 | 0.72 | KDM4E (0.46) | KMT2AHTTMAPTMEN1ALDH1A1 | |
| SCHEMBL22246397 | 0.69 | SMN1; SMN2 (0.39) | ALDH1A1GAA | |
| SCHEMBL14546835 | 0.69 | ALDH1A1 (0.46) | KMT2APOLBL3MBTL1MAPTMEN1 | |
| SCHEMBL23832162 | 0.69 | POLB (0.47) | KMT2AHTTPOLBL3MBTL1MAPT | |
| SCHEMBL24551214 | 0.69 | HEXA (0.36) | KMT2APOLBL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150676-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-07-23 | — | — | WO | disclosed |