Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 3/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2224015 | 0.93 | CYP3A4 (0.41) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2222595 | 0.88 | MAPT (0.50) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2226258 | 0.87 | CYP3A4 (0.49) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2221872 | 0.85 | KCNH2 (0.42) | CYP3A4KCNH2HTR6SFRP1CCNT1 | |
| SCHEMBL2271717 | 0.84 | HTR6 (0.41) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2223299 | 0.84 | HTR6 (0.42) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2220948 | 0.83 | MAPT (0.41) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2276442 | 0.82 | KCNH2 (0.47) | CYP3A4KCNH2HTR6 | |
| SCHEMBL2224695 | 0.81 | HTR6 (0.41) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 | |
| SCHEMBL2278467 | 0.81 | HTR6 (0.41) | CYP3A4CYP2D6KCNH2DRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2521714-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | Suven Life Sciences Limited (IN) | 2012-11-14 | — | — | EP | claimed |
| WO-2011083487-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2011-07-14 | — | — | WO | claimed |
| US-9018231-B2 | Sulfone compounds as 5-HT6 receptor ligands | SUVEN LIFE SCIENCES LIMITED (IN) | 2015-04-28 | — | — | US | disclosed |
| US-20130005709-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2013-01-03 | — | — | US | disclosed |
| EP-2521714-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | Suven Life Sciences Limited (IN) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011083487-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005709-A1 | SULFONE COMPOUNDS AS 5-HT6 RECEPTOR LIGANDS | HTR6, HTR5A, HTR1A | CYP3A4 138/4885CYP2D6 24/4885KCNH2 2828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.