Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17130336 | 0.84 | RAB9A (0.58) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL201736 | 0.82 | GFER (0.72) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL2226112 | 0.82 | LMNA (0.67) | LMNAPOLBGAAKDM4EAR | |
| SCHEMBL2056124 | 0.82 | GFER (0.72) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL27306341 | 0.82 | RAB9A (0.57) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL153338 | 0.81 | HPGD (0.60) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL6760692 | 0.81 | RAB9A (0.56) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL2056125 | 0.81 | TP53 (0.55) | LMNARAB9APOLBNPC1GAA | |
| Bromide SCHEMBL9271730 | 0.81 | RAB9A (0.55) | LMNARAB9APOLBNPC1GAA | |
| SCHEMBL18924618 | 0.80 | SMN1; SMN2 (0.68) | LMNAPOLBKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088181-A9 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | WO | disclosed |
| EP-2533783-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011088181-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |