SCHEMBL22256385

SCHEMBL22256385

O=C(/N=C/c1ccc(C(F)(F)F)cc1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.49
CYP1A1 P04798 1/20 0.49
CYP1B1 Q16678 1/20 0.49
RAB9A P51151 4/20 0.49
NPC1 O15118 3/20 0.49
LMNA P02545 1/20 0.48
PDPK1 O15530 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
MAPT P10636 2/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
PKM P14618 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
KMT2A Q03164 1/20 0.46
RELA Q04206 1/20 0.46
ATM Q13315 1/20 0.46
ESRRG P62508 1/20 0.46
CYP1A2 P05177 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19803857 0.86 PLA2G7 (0.48) RAB9ANPC1SMN1; SMN2MAPTMEN1
SCHEMBL14327772 0.82 PLA2G7 (0.53) MAOBCYP1B1RAB9ANPC1LMNA
SCHEMBL3077773 0.82 PLA2G7 (0.53) MAOBCYP1B1RAB9ANPC1LMNA
SCHEMBL11877420 0.79 LMNA (0.56) RAB9ANPC1LMNASMN1; SMN2MAPT
SCHEMBL11877424 0.79 LMNA (0.56) RAB9ANPC1LMNASMN1; SMN2MAPT
SCHEMBL3022653 0.78 RAB9A (0.51) MAOBCYP1B1RAB9ANPC1LMNA
SCHEMBL27854906 0.77 PLA2G7 (0.71) MAOBCYP1A1CYP1B1RAB9ANPC1
SCHEMBL22256386 0.74 BCHE (0.56) MAOBCYP1B1RAB9ANPC1SMN1; SMN2
SCHEMBL11877403 0.74 TUBB4A (0.52) RAB9ANPC1LMNASMN1; SMN2MAPT
SCHEMBL29190287 0.73 NPC1 (0.51) MAOBCYP1A1CYP1B1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-11664093-B2 Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2023-05-30 US disclosed
US-20200234798-A1 EXTRAPOLATIVE PREDICTION OF ENANTIOSELECTIVITY ENABLED BY COMPUTER-DRIVEN WORKFLOW, NEW MOLECULAR REPRESENTATIONS AND MACHINE LEARNING THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS 2020-07-23 US disclosed