Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28932616 | 0.76 | MAOA (0.43) | SIGMAR1MAOAMAOB | |
| SCHEMBL29098437 | 0.73 | SIGMAR1 (0.50) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| SCHEMBL4895341 | 0.71 | HTR2C (0.37) | HTR2CADRB1SIGMAR1HTR3EHTR3B | |
| SCHEMBL2356063 | 0.71 | HIF1A (0.42) | ADRB1SIGMAR1HTR3EHTR3BHTR3A | |
| SCHEMBL2352069 | 0.70 | KMT2A (0.65) | HTR2CMEN1KMT2AHTR2AHTR1A | |
| SCHEMBL3196430 | 0.70 | HTR2C (0.45) | HTR2CADRB1SIGMAR1HTR3EHTR3B | |
| SCHEMBL11560636 | 0.70 | ADRB1 (0.76) | HTR2CADRB1SIGMAR1HTR3EHTR3B | |
| Piperazine SCHEMBL27720401 | 0.69 | HTR2C (0.60) | HTR2CHTR2AMAOAMAOB | |
| SCHEMBL7884784 | 0.68 | CHRNA7 (0.50) | KMT2AMAOAMAOB | |
| SCHEMBL7052608 | 0.68 | HIF1A (0.50) | ADRB1SIGMAR1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |