Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226172 | 0.89 | ALDH1A1 (0.68) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL2216711 | 0.88 | LMNA (0.80) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL2228000 | 0.88 | LMNA (0.80) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL2227997 | 0.85 | KMT2A (0.68) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL2227993 | 0.81 | KMT2A (0.67) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL2221189 | 0.81 | LMNA (1.00) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL18706162 | 0.80 | MAPT (0.79) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL18706418 | 0.79 | ALDH1A1 (0.74) | ALDH1A1HTTLMNAKMT2ASMYD3 | |
| SCHEMBL18706397 | 0.79 | SMYD3 (1.00) | ALDH1A1HTTKMT2ASMYD3RAB9A | |
| SCHEMBL2226413 | 0.78 | LMNA (0.83) | ALDH1A1HTTLMNAKMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | claimed |
| EP-2357176-A1 | Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 | Hybrigenics S.A. (FR) | 2011-08-17 | — | — | EP | claimed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | claimed |
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |