Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 10/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13718986 | 0.84 | HDAC4 (0.55) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL6912908 | 0.80 | LMNA (0.57) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2228116 | 0.80 | HDAC4 (0.60) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2223637 | 0.80 | ALDH1A1 (0.61) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2227129 | 0.80 | HDAC4 (0.71) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL6914969 | 0.80 | MGLL (0.65) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2226604 | 0.80 | SLC6A7 (0.62) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2223611 | 0.79 | HDAC4 (0.59) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2227381 | 0.79 | HDAC4 (0.67) | MGLLHDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2224997 | 0.78 | HDAC4 (0.66) | MGLLHDAC4HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523664-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088192-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |