Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 5/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 5/20 | 0.49 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226432 | 1.00 | CTSK (0.50) | CTSKHSD11B1DPP4DPP7KCNH2 | |
| SCHEMBL3320633 | 0.84 | CCR1 (0.55) | CTSKDPP4DPP7KCNH2CTSL | |
| SCHEMBL6875228 | 0.84 | USP30 (0.51) | CTSKHSD11B1DPP4DPP7KCNH2 | |
| SCHEMBL6135874 | 0.82 | MEN1 (0.55) | CCR1MEN1KMT2A | |
| SCHEMBL7370466 | 0.80 | ALDH1A1 (0.56) | CTSKCTSLCTSBCTSS | |
| SCHEMBL3321981 | 0.79 | CCR1 (0.48) | CTSKCTSLCTSBCCR1CTSS | |
| SCHEMBL13798752 | 0.79 | MEN1 (0.55) | CTSKCTSLCTSBCCR1CTSS | |
| SCHEMBL7372949 | 0.78 | MMP2 (0.57) | CTSKMEN1KMT2A | |
| SCHEMBL3318502 | 0.77 | SRD5A1 (0.55) | CTSKCTSLCCR1CTSSKMT2A | |
| SCHEMBL3320205 | 0.77 | CCR1 (0.48) | CTSKCTSLCCR1CTSSPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |