Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.63 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226501 | 0.82 | DRD2 (0.62) | DRD2SIGMAR1 | |
| SCHEMBL2229717 | 0.77 | DRD2 (1.00) | DRD2 | |
| SCHEMBL31134492 | 0.76 | ALDH1A1 (0.51) | SIGMAR1TMEM97NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6863952 | 0.75 | JAK2 (0.44) | SIGMAR1TMEM97NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2229131 | 0.74 | TMEM97 (0.47) | SIGMAR1TMEM97NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25342218 | 0.74 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11869851 | 0.74 | TMEM97 (0.47) | HTR7HTR5AHTR6SIGMAR1TMEM97 | |
| SCHEMBL2227321 | 0.73 | HTR6 (0.57) | HTR6 | |
| SCHEMBL18159771 | 0.71 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18149461 | 0.71 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088836-A1 | NOVEL 4-(ARYL-4-SULFONYL)-6,6a,7,8,9,10-HEXAHYDRO-4H-4,8,10a-TRIAZA-ACEPHENANTHRYLENE AND 3-ARYLSULFONYL-6,6a,7,8,9,10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA[C]FLUORENE DERIVATIVES AS SEROTONIN 5-HT6 LIGANDS | H. LUNDBECK A/S (DK) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011088838-A1 | NOVEL 6,6A,7,8,9,10-HEXAHYDRO-4H-4,8,10A-TRIAZA-ACEPHENANTHRYLENE DERIVATIVES AS DOPAMINE D2 LIGANDS | H. LUNDBECK A/S (DK) | 2011-07-28 | — | — | WO | disclosed |