Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30685360 | 0.85 | MEN1 (0.60) | MEN1KMT2AHTR1BALDH1A1ACHE | |
| SCHEMBL26363789 | 0.85 | MEN1 (0.60) | MEN1KMT2AHTR1BALDH1A1ACHE | |
| SCHEMBL22264915 | 0.82 | MEN1 (0.69) | MEN1KMT2AHTR1BALDH1A1KDM4E | |
| SCHEMBL31320844 | 0.82 | MEN1 (0.61) | MEN1KMT2AHTR1BALDH1A1KDM4E | |
| SCHEMBL4472138 | 0.82 | MEN1 (0.61) | MEN1KMT2AHTR1BALDH1A1KDM4E | |
| SCHEMBL4471981 | 0.79 | MEN1 (0.57) | MEN1KMT2AHTR1BALDH1A1KDM4E | |
| SCHEMBL22265010 | 0.78 | ACHE (0.48) | MEN1KMT2AALDH1A1ACHEKDM4E | |
| SCHEMBL12469444 | 0.78 | HPGD (0.51) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL2215886 | 0.78 | TSHR (0.58) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL2215883 | 0.78 | TSHR (0.58) | MEN1KMT2AALDH1A1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3914256-B1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES INC (US) | 2024-05-29 | — | — | EP | disclosed |
| US-11773101-B2 | GPR35 modulators | PROMETHEUS BIOSCIENCES, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210380590-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. | 2021-12-09 | — | — | US | disclosed |
| EP-3914256-A1 | GPR35 MODULATORS | Prometheus Biosciences, Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| CN-113631168-A | GPR35 modulators | 普罗米修斯生物科学公司 | 2021-11-09 | — | — | CN | disclosed |
| US-11053251-B2 | GPR35 modulators | PROMETHEUS BIOSCIENCES, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| WO-2020154492-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| US-20200239476-A1 | GPR35 MODULATORS | PROMETHEUS BIOSCIENCES, INC. | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210380590-A1 | GPR35 MODULATORS | GPR35, GPR55, GPR65 | MEN1 3744/4885KMT2A 4331/4885HTR1B 299/4885 |
| US-11053251-B2 | GPR35 modulators | GPR35, GPR55, GPR65 | MEN1 3744/4885KMT2A 4331/4885HTR1B 299/4885 |
| US-11773101-B2 | GPR35 modulators | GPR35, GPR55, GPR65 | MEN1 3744/4885KMT2A 4331/4885HTR1B 299/4885 |
| US-20200239476-A1 | GPR35 MODULATORS | GPR35, GPR55, GPR65 | MEN1 3744/4885KMT2A 4331/4885HTR1B 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.