Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265281 | 0.88 | HSD11B1 (0.36) | ALDH1A1OPRM1CHRM1CHRM3CHRM5 | |
| SCHEMBL18542859 | 0.80 | NOTUM (0.37) | ALDH1A1OPRM1OPRK1PSEN1PSEN2 | |
| SCHEMBL374161 | 0.71 | ALDH1A1 (0.45) | ALDH1A1OPRM1NPSR1HSD17B10 | |
| SCHEMBL28749828 | 0.69 | OPRM1 (0.38) | ALDH1A1OPRM1CHRM1CHRM3CHRM5 | |
| SCHEMBL105727 | 0.68 | EGFR (0.52) | ALDH1A1CHRM1EGFRCHRM2 | |
| SCHEMBL22452882 | 0.66 | MEN1 (0.39) | ALDH1A1OPRM1NPSR1POLB | |
| SCHEMBL18542893 | 0.66 | MEN1 (0.36) | ALDH1A1OPRM1 | |
| SCHEMBL22265647 | 0.65 | GAA (0.39) | ALDH1A1TRPA1POLB | |
| SCHEMBL20601546 | 0.63 | OPRM1 (0.52) | ALDH1A1OPRM1OPRK1HSD11B1NPSR1 | |
| SCHEMBL24680602 | 0.63 | NPSR1 (0.42) | ALDH1A1NPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089541-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | EXELIXIS, INC. | 2022-03-24 | — | — | US | disclosed |
| EP-3914356-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | Exelixis, Inc. (US) | 2021-12-01 | — | — | EP | disclosed |
| WO-2020154610-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
| WO-2020154610-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2020-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089541-A1 | Compounds for the Treatment of Kinase-Dependent Disorders | PRKDC, MAP3K20, BRAF | ALDH1A1 3309/4885OPRM1 4289/4885OPRK1 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.