Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 1.00 |
| ▸ | CASP3 | P42574 | 3/20 | 1.00 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 1.00 |
| ▸ | NQO2 | P16083 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19431244 | 0.86 | NPC1 (0.76) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL4141962 | 0.84 | MEN1 (0.89) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL11739871 | 0.83 | RAB9A (0.71) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL1353484 | 0.83 | NPC1 (0.71) | NPC1RAB9ACASP3SENP7NQO2 | |
| Hydrochloric Acid SCHEMBL9638131 | 0.82 | MEN1 (0.86) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL3503370 | 0.82 | NPC1 (0.84) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL4248720 | 0.82 | RXFP1 (0.76) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL3788361 | 0.81 | NPC1 (1.00) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL12218571 | 0.81 | CASP3 (1.00) | NPC1RAB9ACASP3SENP7NQO2 | |
| SCHEMBL5492048 | 0.81 | RAB9A (0.75) | NPC1RAB9ACASP3SENP7NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | claimed |
| WO-2011091209-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-07-28 | — | — | WO | claimed |
| US-20140213632-A1 | HCV Combination Therapy | STELLA APS (DK) | 2014-07-31 | — | — | US | disclosed |
| US-20140127159-A1 | HCV Combination Therapy | STELLA APS (DK) | 2014-05-08 | — | — | US | disclosed |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | disclosed |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | disclosed |
| WO-2011091209-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011091209-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140127159-A1 | HCV Combination Therapy | HAVCR2, EIF2AK2, TIMP3 | NPC1 682/4885RAB9A 3808/4885CASP3 401/4885 |
| US-20140213632-A1 | HCV Combination Therapy | HAVCR2, EIF2AK2, ZC3HAV1 | NPC1 711/4885RAB9A 3673/4885CASP3 2636/4885 |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | HAVCR2, CCAR2, EIF2AK2 | NPC1 2842/4885RAB9A 2851/4885CASP3 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.