Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 16/20 | 0.84 |
| ▸ | RAB9A | P51151 | 16/20 | 0.84 |
| ▸ | MEN1 | O00255 | 9/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.70 |
| ▸ | CASP3 | P42574 | 4/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.69 |
| ▸ | NQO2 | P16083 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PLG | P00747 | 1/20 | 0.62 |
| ▸ | PLAU | P00749 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26885202 | 0.95 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2229842 | 0.94 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8081011 | 0.93 | DEGS1 (0.82) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL3660083 | 0.93 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2681024 | 0.92 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2230642 | 0.92 | NPC1 (0.77) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8420152 | 0.92 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL26885214 | 0.90 | DEGS1 (0.72) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL26885197 | 0.90 | PTPN1 (0.73) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7964170 | 0.89 | RAB9A (0.73) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | THE WISTAR INSTITUTE (US) | 2016-03-10 | — | — | US | disclosed |
| US-9234230-B2 | Screening method and compounds for modulating telomerase activity | THE WISTAR INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-8377992-B2 | TRBD-binding effectors and methods for using the same to modulate telomerase activity | THE WISTAR INSTITUTE (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | THE WISTAR INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
| US-20100160260-A1 | TRBD-Binding Effectors and Methods for Using the Same to Modulate Telomerase Activity | THE WISTAR INSTITUTE | 2010-06-24 | — | — | US | disclosed |
| US-5043399-A | Blend of acetal resin and transparent polyamide elastomer | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1991-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309759-A1 | Screening Method and Compounds for Modulating Telomerase Activity | TERT, TERB1, TERF2 | NPC1 3713/4885RAB9A 3522/4885MEN1 3807/4885 |
| US-20160067257-A1 | SCREENING METHOD AND COMPOUNDS FOR MODULATING TELOMERASE ACTIVITY | TERT, TERB1, TERF2 | NPC1 3713/4885RAB9A 3522/4885MEN1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.