Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18448288 | 0.83 | HTR6 (0.41) | RORCHTR6NUDT1ADRA2AADRA2B | |
| SCHEMBL19205732 | 0.83 | HTR6 (0.41) | RORCHTR6NUDT1ADRA2AADRA2B | |
| SCHEMBL18449630 | 0.83 | HTR6 (0.41) | RORCHTR6NUDT1ADRA2AADRA2B | |
| SCHEMBL19205707 | 0.78 | ADRA2A (0.44) | HTR6ADRA2AADRA2BADRA2CMAPK1 | |
| SCHEMBL18485952 | 0.78 | ADRA2A (0.44) | HTR6ADRA2AADRA2BADRA2CMAPK1 | |
| SCHEMBL18447791 | 0.78 | ADRA2A (0.44) | HTR6ADRA2AADRA2BADRA2CMAPK1 | |
| SCHEMBL22270578 | 0.74 | ALDH1A1 (0.47) | MAPK14 | |
| SCHEMBL18485943 | 0.67 | L3MBTL1 (0.36) | ADRA2AADRA2BADRA2CMAPK1AURKB | |
| SCHEMBL31461385 | 0.66 | HTR6 (0.46) | RORCHTR6NUDT1ADRA2AADRA2B | |
| SCHEMBL21254721 | 0.66 | ALOX5AP (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3686187-A1 | PROCESS FOR THE PREPARATION OF ROR GAMMA MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2020-07-29 | — | — | EP | disclosed |