Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.36 |
| ▸ | GRN | P28799 | 3/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22271602 | 1.00 | FPR2 (0.39) | FPR2ACACBACACACTSSCTSK | |
| SCHEMBL20013297 | 0.85 | ACACB (0.38) | ACACBACACAGRNSORT1MME | |
| SCHEMBL24693135 | 0.84 | FOLH1 (0.40) | ACACBACACANOD1GRNSORT1 | |
| SCHEMBL8738364 | 0.80 | FPR2 (0.44) | FPR2CTSSCTSKNOD1GRN | |
| SCHEMBL11737186 | 0.75 | FPR2 (0.43) | FPR2CTSSCTSKNOD1GRN | |
| SCHEMBL25028556 | 0.75 | ACACB (0.39) | ACACBACACAGRNSORT1MME | |
| SCHEMBL11737182 | 0.75 | FPR2 (0.43) | FPR2CTSSCTSKNOD1GRN | |
| SCHEMBL67061 | 0.72 | CTSK (0.66) | CTSSCTSK | |
| SCHEMBL1231627 | 0.72 | CTSK (0.66) | CTSSCTSK | |
| SCHEMBL3450517 | 0.72 | CTSK (0.66) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218392-B1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-07-29 | — | — | EP | disclosed |