Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 10/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.31 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688114 | 0.83 | TYK2 (0.41) | TYK2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL20689612 | 0.83 | TYK2 (0.40) | TYK2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL20689613 | 0.71 | FAAH (0.36) | TYK2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16727213 | 0.69 | CYP1A2 (0.42) | — | |
| SCHEMBL16727195 | 0.66 | AR (0.46) | — | |
| SCHEMBL30993024 | 0.66 | TYK2 (0.42) | TYK2CNR2SLC6A4 | |
| SCHEMBL25418170 | 0.64 | IDO1 (0.49) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL17739571 | 0.64 | METAP2 (0.42) | TYK2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL25293329 | 0.63 | CHRNB2 (0.36) | SLC6A4 | |
| SCHEMBL29559817 | 0.62 | MEN1 (0.47) | SHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154474-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-07-30 | — | — | WO | disclosed |