Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22280479 | 0.87 | MAPK1 (0.49) | SPHK2SPHK1HSD11B1GRM5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL22265416 | 0.84 | SPHK2 (0.56) | SPHK2SPHK1HTTPOLB | |
| Hydrochloric Acid SCHEMBL22265409 | 0.84 | SPHK2 (0.56) | SPHK2SPHK1HTTPOLB | |
| SCHEMBL22280491 | 0.84 | SMO (0.47) | SPHK2HSD11B1GRM5ALDH1A1SMN1; SMN2 | |
| SCHEMBL22280492 | 0.83 | SPHK2 (0.41) | SPHK2SPHK1HSD11B1GRM5CLPP | |
| SCHEMBL22280443 | 0.82 | HDAC6 (0.49) | HSD11B1GRM5CLPPALDH1A1SMN1; SMN2 | |
| SCHEMBL22280465 | 0.82 | RAB9A (0.60) | SPHK2SPHK1HSD11B1GRM5CLPP | |
| SCHEMBL22280439 | 0.82 | RAB9A (0.60) | SPHK2SPHK1HSD11B1GRM5CLPP | |
| Hydrochloric Acid SCHEMBL22265417 | 0.81 | SPHK2 (0.46) | SPHK2SPHK1HSD11B1GRM5CLPP | |
| SCHEMBL22280622 | 0.80 | HSD11B1 (0.63) | SPHK2SPHK1HSD11B1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |