Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302299 | 0.78 | ACACB (0.68) | MAPTNPC1RAB9ASMN1; SMN2ACACB | |
| SCHEMBL3505092 | 0.77 | L3MBTL1 (0.55) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL22280486 | 0.77 | SMPD1 (0.53) | PPARDPPARAACACBS1PR1S1PR3 | |
| SCHEMBL19430486 | 0.74 | ACACB (0.46) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL20657658 | 0.74 | S1PR1 (0.54) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL20671526 | 0.74 | S1PR1 (0.54) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL20657656 | 0.74 | S1PR1 (0.54) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL19091431 | 0.72 | S1PR1 (0.61) | MAPTNPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7297949 | 0.72 | RAB9A (0.50) | PPARDPPARAMAPTNPC1RAB9A | |
| SCHEMBL15671605 | 0.69 | S1PR1 (0.49) | PPARDPPARAMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154431-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | LYNCH KEVIN R (US) | 2020-07-30 | — | — | WO | disclosed |