Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.65 |
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | PRKCI | P41743 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1452104 | 0.88 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL12469188 | 0.87 | ATG4B (0.69) | RAB9ANPC1LMNAHIF1AKMT2A | |
| SCHEMBL31520136 | 0.82 | LMNA (0.61) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL28055749 | 0.81 | POLB (0.66) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL12707716 | 0.81 | LMNA (0.73) | RAB9ANPC1LMNAHIF1ANAMPT | |
| SCHEMBL12010995 | 0.80 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL12074337 | 0.80 | HSD17B10 (0.63) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL259290 | 0.80 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL30354911 | 0.80 | PRKCI (0.61) | RAB9ANPC1SMN1; SMN2LMNAHIF1A | |
| SCHEMBL29151323 | 0.80 | PRKCI (0.61) | RAB9ANPC1SMN1; SMN2LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406877-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-04-14 | — | — | EP | claimed |
| WO-2003004475-A1 | HETEROCYCLIC AMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |
| WO-2011089416-A1 | PYRAZINE DERIVATIVES | ASTRAZENECA AB (SE) | 2011-07-28 | — | — | WO | disclosed |
| CN-101394851-A | Gsk-3 inhibitors for the treatment of osteoporosis | ASTRAZENECA AB (SE) | 2009-03-25 | — | — | CN | disclosed |