Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | CFD | P00746 | 3/20 | 0.57 |
| ▸ | F11 | P03951 | 3/20 | 0.57 |
| ▸ | TPSB2 | P20231 | 3/20 | 0.57 |
| ▸ | PLG | P00747 | 1/20 | 0.57 |
| ▸ | PLAU | P00749 | 1/20 | 0.57 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.57 |
| ▸ | F7 | P08709 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.54 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412911 | 0.98 | HTR1A (0.59) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL1462035 | 0.87 | HTR1A (0.57) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL31757878 | 0.87 | HTR1A (0.57) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL1007508 | 0.86 | CFD (0.68) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL31757965 | 0.86 | CFD (0.68) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL68571 | 0.83 | L3MBTL1 (0.69) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL29291239 | 0.83 | GAA (0.54) | HTR1ADRD2CFDF11TPSB2 | |
| SCHEMBL9732671 | 0.82 | PTGER1 (0.57) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL16397532 | 0.82 | CFD (0.56) | CFDF11TPSB2PLGPLAU | |
| SCHEMBL8324677 | 0.82 | L3MBTL1 (0.64) | HTR1ADRD2CFDF11TPSB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3917627-A1 | ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160134-A1 | ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-08-06 | — | — | WO | disclosed |