Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.52 |
| ▸ | CFD | P00746 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | F11 | P03951 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.52 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5661211 | 0.89 | TBXAS1 (0.53) | L3MBTL1ALDH1A1MAPK1HTR1ADRD2 | |
| SCHEMBL8015205 | 0.89 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1MAPK1CFDPLG | |
| SCHEMBL2988197 | 0.86 | L3MBTL1 (0.56) | L3MBTL1ALDH1A1HTR1ADRD2PTGER1 | |
| SCHEMBL31757763 | 0.86 | L3MBTL1 (0.56) | L3MBTL1ALDH1A1HTR1ADRD2PTGER1 | |
| SCHEMBL8682147 | 0.86 | L3MBTL1 (0.54) | L3MBTL1ALDH1A1MAPK1HTR1ADRD2 | |
| SCHEMBL1007508 | 0.85 | CFD (0.68) | L3MBTL1ALDH1A1HTR1ADRD2PTGER1 | |
| SCHEMBL31757965 | 0.85 | CFD (0.68) | L3MBTL1ALDH1A1HTR1ADRD2PTGER1 | |
| SCHEMBL9774023 | 0.84 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL1412911 | 0.83 | HTR1A (0.59) | L3MBTL1ALDH1A1HTR1ADRD2PTGER1 | |
| SCHEMBL9003138 | 0.82 | HRH1 (0.61) | L3MBTL1ALDH1A1MAPK1DRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1996011902-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-04-25 | — | — | WO | disclosed |