SCHEMBL22290897

SCHEMBL22290897

CN1CCC(OCc2cccc(B3OC(C)(C)C(C)(C)O3)c2)C(F)(F)C1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LIPG Q9Y5X9 2/20 0.42
LPL P06858 1/20 0.42
TDP2 O95551 1/20 0.33
CARM1 Q86X55 5/20 0.33
PRMT6 Q96LA8 5/20 0.33
PRMT8 Q9NR22 2/20 0.33
BACE1 P56817 2/20 0.32
ROCK1 Q13464 1/20 0.31
DGAT1 O75907 1/20 0.30
PRMT3 O60678 1/20 0.30
SSTR4 P31391 1/20 0.30
CHRM2 P08172 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22290622 0.82 LPL (0.47) LIPGLPLCARM1PRMT6PRMT8
SCHEMBL31173419 0.81 CARM1 (0.49) CARM1PRMT6PRMT8
SCHEMBL22290830 0.81 CARM1 (0.49) CARM1PRMT6PRMT8
SCHEMBL22291043 0.78 LIPG (0.49) LIPGLPLTDP2CARM1PRMT6
SCHEMBL1362568 0.74 LIPG (0.50) LIPGLPLCARM1PRMT6PRMT8
SCHEMBL24493122 0.74 PRMT6 (0.35) CARM1PRMT6PRMT8SSTR4
SCHEMBL22290349 0.73 LIPG (0.49) LIPGLPLTDP2CARM1PRMT6
SCHEMBL22290754 0.72 LIPG (0.48) LIPGLPLTDP2CARM1PRMT6
SCHEMBL19499255 0.72 NTRK1 (0.42) BACE1ROCK1SSTR4
SCHEMBL22290682 0.71 LIPG (0.47) LIPGLPLTDP2CARM1PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3917527-B1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC (US) 2025-04-23 EP disclosed
US-20230079819-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2023-03-16 US disclosed
EP-3917527-A1 COMPOUNDS AND USES THEREOF Foghorn Therapeutics Inc. (US) 2021-12-08 EP disclosed
CN-113645971-A Compound and use thereof 福宏治疗公司 2021-11-12 CN disclosed
WO-2020160180-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. (US) 2020-08-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230079819-A1 COMPOUNDS AND USES THEREOF VHL, CLN6, TFEB LIPG 2836/4885LPL 1810/4885TDP2 579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.