Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 12/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239282 | 0.87 | TMEM97 (0.52) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL25415646 | 0.86 | SIGMAR1 (0.42) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL29266142 | 0.84 | ALDH1A1 (0.43) | HRH3MEN1KMT2ALMNAMAPT | |
| SCHEMBL5229150 | 0.81 | TMEM97 (0.56) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL5237843 | 0.81 | KMT2A (0.54) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL5232705 | 0.80 | MEN1 (0.53) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL22290980 | 0.79 | LMNA (0.57) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL5235413 | 0.78 | TMEM97 (0.51) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL5231132 | 0.77 | NPSR1 (0.50) | TMEM97SIGMAR1HTR1AADRA2CHRH2 | |
| SCHEMBL19950156 | 0.77 | MEN1 (0.60) | TMEM97SIGMAR1HTR1AADRA2CHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677341-B | Bicyclic pyridine compositions and methods for their use in cancer treatment | 南卡罗莱纳大学 | 2024-07-05 | — | — | CN | disclosed |
| US-11572369-B2 | Bicyclic pyridine compositions and methods of using the same for cancer therapy | UNIVERSITY OF SOUTH CAROLINA (US) | 2023-02-07 | — | — | US | disclosed |
| US-20220135583-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA | 2022-05-05 | — | — | US | disclosed |
| EP-3917523-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | University of South Carolina (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160537-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160537-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | UNIVERSITY OF SOUTH CAROLINA (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220135583-A1 | BICYCLIC PYRIDINE COMPOSITIONS AND METHODS OF USING THE SAME FOR CANCER THERAPY | DPYD, TK2, TYMP | TMEM97 4623/4885SIGMAR1 4525/4885HTR1A 3888/4885 |
| US-11572369-B2 | Bicyclic pyridine compositions and methods of using the same for cancer therapy | DPYD, TK2, TYMP | TMEM97 4623/4885SIGMAR1 4525/4885HTR1A 3888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.